Antox® and Bactofort® Improved Alterations in Oxidative Stress Biomarkers Induced by a Very Virulent Infectious Bursal Disease Virus in ISA Brown Chicks


  • Paul Abdu Department of Veterinary Medicine, Ahmadu Bello University, Zaria, Nigeria
  • Aliyu Danlamin Andamin Department of Veterinary Pathology, Ahmadu Bello University, Zaria, Nigeria
  • Ochuko Orakpoghenor Department of Animal Health Technology, Taraba State College of Agriculture Jalingo, Nigeria
  • Felix Tersua Akade Department of Veterinary Pharmacology and Toxicology, Ahmadu Bello University, Zaria, Nigeria
  • Dahiru Sani Department of Veterinary Physiology, Ahmadu Bello University, Zaria, Nigeria
  • Tagang Aluwong Department of Veterinary Microbiology, Ahmadu Bello University, Zaria, Nigeria
  • Talatu Patience Markus Regional Disease Surveillance Systems Enhancement (REDISSE) Project, Nigeria



Antox®, Bactofort®, Infectious bursal disease,, Oxidative stress biomarkers


This study investigated the ameliorative effects of Antox® and Bactofort® on some oxidative stress biomarkers in ISA Brown chicks inoculated with a vvIBDV. Two hundred one-day-old ISA Brown chicks were assigned into four groups of 50 birds each. Groups A and B were supplemented with Antox®, and Bactofort® respectively from 1 to 42 days of age, and inoculated with vvIBDV at 28 days of age, while C and D served as positive and negative controls. Sera collected from chicks at 1, 14, 28, 35, and 42 days of age were analyzed for activities of superoxide dismutase (SOD), catalase (CAT), glutathione perioxidase (GPx), malondialdehyde (MDA) concentration, and erythrocyte osmotic fragility (EOF). Results revealed significantly (p < 0.05) increased SOD activity, decreased CAT and GPx activities, decreased MDA concentration and EOF in groups administered Antox®, and Bactofort® compared to positive control at 7 (day 35) and 14 (day 42) days post-inoculation. In conclusion, Antox® and Bactofort® ameliorated the deleterious effects of vvIBDV on SOD, CAT and GPx activities, MDA concentration, and EOF. Antox® and Bactofort® could be used to ameliorate vvIBDV-induced oxidative changes and further studies should be carried out to determine their possible adverse effects when administered for preventive purposes.

Author Biographies

Paul Abdu, Department of Veterinary Medicine, Ahmadu Bello University, Zaria, Nigeria

Department of Veterinary Medicine - Professor

Aliyu Danlamin Andamin, Department of Veterinary Pathology, Ahmadu Bello University, Zaria, Nigeria

Department of Veterinary Medicine

Felix Tersua Akade, Department of Veterinary Pharmacology and Toxicology, Ahmadu Bello University, Zaria, Nigeria

Department of Animal Health Technology

Dahiru Sani, Department of Veterinary Physiology, Ahmadu Bello University, Zaria, Nigeria

Department of Veterinary Pharmacology and Toxicology

Tagang Aluwong, Department of Veterinary Microbiology, Ahmadu Bello University, Zaria, Nigeria

Department of Veterinary Physiology

Talatu Patience Markus, Regional Disease Surveillance Systems Enhancement (REDISSE) Project, Nigeria

Department of Veterinary Microbiology


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How to Cite

Abdu, P., Andamin, A. D. ., Orakpoghenor, O., Akade, F. T. ., Sani, D., Aluwong, T., & Markus, T. P. . (2023). Antox® and Bactofort® Improved Alterations in Oxidative Stress Biomarkers Induced by a Very Virulent Infectious Bursal Disease Virus in ISA Brown Chicks. Scientific Reports in Life Sciences, 4(1), 69–84.